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Articles under review in peer-reviewed journals:

  1. Al-Jaber H, Al-Mansoori L, Al-Muraikhy S, Agouni A, Kafienah Q, Elrayess MA. The influence of adipose tissue’s inflammatory microenvironment on preadipocyte proliferation and adipogenic potential. Submitted – Cytokine.
  2. Alshabrmi FM, Khan A, Agouni A, Wei DQ. Deciphering the Mechanism of Novel Androgen Receptor Mutations in Resistance to Enzalutamide in Prostate Cancer via Protein Structural Graphs, Molecular interactions, and biophysical simulations. Submitted – International Journal of Biological Macromolecules.
  3. Kerkadi A, Al Attieh N, Al Mahmoud S, Saeed K, Attieh G, Rahman MD, Soltani A, Shi Z and Agouni A. Relationship Between Adiposity Indices and Bone Mineral Density at Different Sites Among Females in Qatar. Under Review – Frontiers in Endocrinology.
  4. Ibrahim M, Sayaf AM, Yeoh K, Ali M, Ali S, Ullah S, Khan A, Agouni A*. Synthesis, evaluation, and in silico validation of 5-nitro-1H-benzo[d]imidazole-2(3H)-thione and acyl hydrazone derivatives. *Corresponding author. Under Review – Bioorganic & Medicinal Chemistry.
  5. Alsharbmi FM, Khan A, Agouni A, Wei DQ. Structural elucidation of the impact of S30L and D88N mutations on the structure of Late transcription factor 1 (G9R) and binding mechanism of G9R-E4R complex from Monkeypox virus. Under Review – Interdisciplinary Sciences: Computational Life Sciences.
  6. Khan A, Suleman M, Alsharbmi FM, Ait Hssain A, Waheed Y, Munir M; Crovella S, Agouni A*. Preliminary structural data on the pathogenicity of JN.1 and BA.2.86 variants of SARS-CoV-2: Latest players in the game. *Corresponding author. Submitted – ACS Omega.
  7. Suleman M, Khan A, Fazal Akbar, Albekairi NA, Agouni A*, Crovella S*. Structural engineering of highly specific pro-apoptotic peptides against the BFL-1 interface to instigate apoptosis in colorectal cancer. *Corresponding authors. Submitted – Life Sciences.
  8. Hasan M, Mutlu O, Sajidul Islam M, Shurbaji S, Sulaiman R, Elsharabassi Y, Agouni A, Yalcin HC. Oscillatory flow enhances inflammatory and oxidative stress markers in endothelial cells. Submitted – Journal of Cardiology.Impact factor 2.5
  9. Abrar Mohammad Sayaf, Muhammad Suleman, Sergio Crovella, Abbas Khan, Noorah Albekairi, AbdulRahman Alshammari, Latipah Binti Latip, Abdelali Agouni*, Kar Kheng Yeoh*. Integrative Computational Approach Identifies Potent EGFR Inhibitors from Natural Chemical Space using Virtual Screening, Molecular Dynamics Simulations, and DeepAutoQSAR Modelling. *Corresponding authorw.  Submitted – Artificial Intelligence Chemistry.Impact factor 2.5
  10. Sayaf AM, Suleman M, Albekairi NA, Alshammari A, Khan A, Agouni A*, Yeoh KK*. Evaluation of 2-(1H-1,2,3-triazol-1-yl)acetic acid derivatives as potential human hypoxia inducible factor (HIF) prolyl hydroxylase domain-2 (PHD2) inhibitors. Submitted – Pure and Applied Chemistry
  11. Khan A, Ali SS, Zahid MA, Alsharbmi FM, Al-Zoubi RM, Shkoor M, Agouni A*. Microsecond simulations to investigate the structural mechanism of super resistant double mutations in BTK to covalent inhibitor Ibrutinib in multiple leukemia. *Corresponding author. Under Review –Journal of Cellular and Molecular Medicine.
  12. Bader L, Parray A, Akhtar N, Raïq H, Pananchikkal SV, Thazhe Kuni RA, Pir RJ, Joseph S, Morgan DM, Babu B, Ty Ui R, Sivasankaran S, Own S, Shuaib A, Agouni A*. The Association Between Plasma Levels of Sestrin2 and the Risk of Acute Ischemic Stroke in Qatar. *Corresponding author. Under Review – Journal of Cellular and Molecular Medicine.
  13. Zahid MA, Abdelsalam AA, Raïq H, Abunada HH, Parray A, Agouni A*. Association of plasma levels of Sestrin2 with adiposity and metabolic function indices in healthy and diabetic subjects from Qatar Biobank. *Corresponding author. Under Review – Frontiers in Endocrinology.Impact factor 3.9 (Q2).
  14. Parray A, Akhtar N, Sivaraman SK, Raïq H, Prince MS, Pananchikkal SV, Thazhe Kuni RA, Pir RJ, Joseph S, Morgan DM, Babu B, Ty Ui R, Sivasankaran S, Own S, Shuaib A, Agouni A*. The Relationship of Circulating Extracellular Vesicles to Small Vessel Disease in Acute Ischemic Stroke. *Corresponding author. Under review – Journal of Genetic Engineering and Biotechnology.
  15. Sawali MA, Abdelsalam SS, Zahid MA, Al-Zoubi RM, Shkoor M, Agouni A*. Unraveling the Role of Protein Tyrosine Phosphatase 1B in Cardiometabolic Disorders and its Interplay with Endothelial Dysfunction. *Corresponding authors.  Submitted – Biomedicine and Pharmacotherapy.
  16. Ghanem SK, Abdelsam SS, Bader L, Agouni A*. Large Extracellular Vesicles (Microvesicles) in Diabetic Nephropathy: A Systematic Review of Preclinical Studies. *Corresponding authors.  Submitted – Journal of Cellular Physiology.

Articles in revision in peer-reviewed journals:

  1. Sayaf AM, Suleman M, Albekairi NA, Alshammari A, Khan A, Agouni A*, Yeoh KK*. In Silico Explorations and Molecular Simulation-based Validation of Synthetic and Natural Products Databases for Hypoxia Inducible Factor (HIF) Prolyl Hydroxylase Domain (PHD) Inhibitors Discovery. *Corresponding authors.  Revision – Scientific Reports.
  2. Khan A, Sayaf AM, Alshamari A, Benameur T, Yeoh KK, Agouni A*. Theoretical Insights into the Multi-target inhibition of Ebola Virus with Medicinal Phytocompounds Using Molecular Screening, biophysical Simulation, and Binding free energy calculations. *Corresponding author. Revision – Journal of Infection and Public Health. Impact factor 4.7 (Q1).

Articles Accepted/Published in peer-reviewed journals:

  1. Sayaf AM, Kousar K, Suleman M, Albekairi NA, Alshammari A, Mohammad A, Khan A, Agouni A*, Yeoh KK*. Molecular Exploration of Natural and Synthetic Compounds databases for Promising Hypoxia Inducible Factor (HIF) Prolyl-4 Hydroxylase Domain (PHD) Inhibitors using molecular simulation and free energy calculations. *Corresponding authors. BMC Chemistry 2024, in press.Impact factor 4.3 (Q2).
  2. Hussain FN, Al-Mannai R, Agouni A*. Quantitative analysis, and evaluation on the use of archived lecture capture recordings by undergraduate pharmacy students during the emergency switch to distance-based learning following COVID-19 pandemic. *Corresponding author. Cureus 2024, in press. Impact factor 1.0 (Q3).
  3. Abdelsalam AA, Zaid MA, Raïq H, Abunada HH, Parray A, Agouni A*. The Association between Plasma Levels of Sestrin2 and Risk Factors of Cardiovascular Diseases in Healthy and Diabetic Adults: A Study of Qatar Biobank Data. *Corresponding author. Biomolecules and Biomedicine 2024, in press.Impact factor 3.1 (Q2).
  4. Mazhar N, Sajidul Islam M, Raza MZ, Chowdhury MEH, Al-Ali A, Agouni A, Yalcin HC. Comparative Analysis of In-Vitro Pumps used in Cardiovascular Investigations: Focus on flow generation principles and characteristics of generated flows. Bioengineering 2024, 11(11):1116.Impact factor 3.8 (Q2). DOI: https://doi.org/10.3390/bioengineering11111116
  5. Khan A, Ali SS, Zahid MA, Abdelsalam SS, Alshamari A, Hassan F, Al-Zoubi RM, Shkoor M, Wei DQ*, Agouni A*. Analysis of the non-synonymous substitutions and conformational dynamics revealed the impact of deleterious mutations on the coupling of RAF1-RAP1A in cancer. *Corresponding author. PROTEINS 2024, 0:1–18.Impact factor 3.2 (Q2). DOI: https://doi.org/10.1002/prot.26759
  6. Khan A, Mohammad A, Alshammarri A, Zahid MA, Al-Zoubi RM, Shkoor M, Benameur T, Agouni A*. Curcumin as a Potential Antidiabetic Agent: Insights from Network Pharmacology, Molecular Docking and Simulation Studies. *Corresponding author. ChemistrySelect 2024, 9:e202402379.Impact factor 1.9 (Q3). DOI: https://doi.org/10.1002/slct.202402379
  7. Pir RJ, Zahid MA, Akhtar N, Sivaraman SK, Raïq H, Prince MS, Pananchikkal SV, Thazhe Kuni RA, Joseph S, Morgan DM, Babu B, Ty Ui R, Sivasankaran S, Own S, Shuaib A, Parray A, Agouni A*. Altered Plasma Exosomal miRNA Profile of Acute Ischemic Stroke Patients: A Functional Analysis. *Corresponding author. Brain Research 2024, 1845:149171.Impact factor 2.7 (Q3). DOI: https://doi.org/10.1016/j.brainres.2024.149171
  8. Al-Zoubi RM, Al-Jammal WK, Shkoor M, Bani-Yaseen A, Khan A, Agouni A, McDonald R. Efficient, Regioselective Synthesis of Ortho-Diiodinated Homobenzylic Alcohol Derivatives: In-Silico Evaluation as Potential Anticancer IDO/TDO Inhibitors. Organic & Biomolecular Chemistry 2024, 22:7395-7410.Impact factor 2.9 (Q1). DOI: https://doi.org/10.1039/D4OB01076K
  9. Khan A, Zahid MA, Abdelsalam SS, Mohammad A, Al-Zoubi RM, Shkoor S, Ait Hssain A, Wei DQ, Agouni A*. Integrated Structural Proteomics and Machine Learning-based Approach to Design a Highly Protective Precision Vaccine Against Mycoplasma Pulmonis. *Corresponding author. International Immunopharmacology 2024, 141:112833. Impact factor 4.8 (Q1). DOI: https://doi.org/10.1016/j.intimp.2024.112833
  10. Khan A, Ali SS, Zahid MA, Alshabrmi FM, Agouni A*. Structural proteomics guided annotation of vaccine targets and designing of multi-epitopes vaccine to instigate adaptive immune response against Francisella tularensis. *Corresponding author. Microbial Pathogenesis 2024, 194:106777. Impact factor 3.3 (Q2). DOI: https://doi.org/10.1016/j.micpath.2024.106777
  11. Ahmed A, Al-Nuaimi SR, Mustafa A, Zeidan A, Agouni A, and Laiche Djouhri. Kv7 channel activators Flupirtine and ML213 alleviate neuropathic pain behavior in the streptozotocin rat model of diabetic neuropathy.Journal of Pain Research 2024, 17:2267-2278. Impact factor 2.5 (Q2). DOI: https://doi.org/10.2147/JPR.S467535
  12. Ali L, Rauf S, Khan A, Raza RZ, Alshabrmi FM, Khan T, Suleman M, Waheed Y, Agouni A*. Computational Immune Epitopes Screening in the Proteome of Hantavirus to Design Next-generation Highly Antigenic Vaccine and Validation using Immune Simulation. *Corresponding author.  PLOS ONE  2024, 19(7):e0305417. Impact factor 2.9 (Q2). DOI: https://doi.org/10.1371/journal.pone.0305417
  13. Suleman M, Sayaf AM, Khan A, Albekairi NA, Alshammari A, Agouni A*, Yassine HM*, Crovella S*. Molecular screening of phytocompounds targeting the interface between influenza A NS1 and TRIM25 to enhance host immune responses. *Corresponding authors. Journal of Infection and Public Health 2024, 17(7):102448. Impact factor 6.7 (Q1). DOI: https://doi.org/10.1016/j.jiph.2024.05.005
  14. Khan A, Zahid MA, Shahab M, Al-Zoubi RM, Shkoor M, Benameur T, Agouni A*. Investigating the role of functional mutations in Leucine binding to Sestrin2 in aging and age-associated degenerative pathologies using structural and molecular simulation approaches. *Corresponding author.Journal of Biomolecular Structure and Dynamics 2024, 30:1-13. Impact factor 4.4 (Q1). DOI: https://doi.org/10.1080/07391102.2024.2335289
  15. Khan A, Zahid MA, Mohammad A, Agouni A*.Structure-guided 1 engineering and molecular simulations to design a potent monoclonal antibody to target aP2 antigen for adaptive immune response instigation against type 2 diabetes. *Corresponding author. Frontiers in Immunology 2024, 15:1357342. Impact factor 7.3 (Q1). DOI: https://doi.org/10.3389/fimmu.2024.1357342
  16. Abdelsalam SS, Ghanem SK, Zahid MA, Bader L, Abunada H, Raïq H, Khan A, Parray A, Djouhri L, Agouni A*. Human Antigen R: Exploring its Impact on Inflammatory Response and its Significance in Cardiometabolic Disorders. *Corresponding author. Journal of Cellular Physiology 2024, in press. Impact factor 5.6 (Q1). DOI: https://doi.org/10.1002/jcp.31229
  17. Khan A, Waheed Y, Kuttikrishnan S, Prabhu KS, El-Elimat T, Uddin S, Alali FQ, Agouni A*. Network Pharmacology, Molecular Simulation, and binding free energy calculation-based investigation of Neosetophomone B revealed key targets for the treatment of cancer. *Corresponding author. Frontiers in Pharmacology 2024, 15:1352907.  Impact factor 5.6 (Q1). DOI: https://doi.org/10.3389/fphar.2024.1352907
  18. Suleman M*, Khattak A, Fazal Akbar, Rizwan M, Tayyab M, Yousaf M, Khan A, Albekairi NA, Agouni A*, Crovella S*. Analysis of E2F1 Single-Nucleotide Polymorphisms Reveals Deleterious Non2 synonymous Substitutions that Disrupt E2F1-RB Protein Interaction in Cancer. *Corresponding authors. International Journal of Biological Macromolecules 2024, 260:129559.Impact factor 8.2 (Q1). DOI: https://doi.org/10.1016/j.ijbiomac.2024.129559
  19. Kerkadi A, Raïq H, Prince MS, Bader L, Soltani A, Agouni A*. A Cross-sectional Analysis of Zinc and Copper Levels and Their Relationship to Cardiovascular Disease Risk Markers in Qatar Biobank Participants. *Corresponding author. Frontiers in Cardiovascular Medicine 2023, 10:1305588. Impact factor 3.6 (Q2). DOI: https://doi.org/10.3389/fcvm.2023.1305588
  20. Abujamous L, Soltani A, AL-Thawadi H, Agouni A*. Advances in Nanotechnology-Enabled Drug Delivery for Combining PARP Inhibitors and Immunotherapy in Advanced Ovarian Cancer. *Corresponding author. Biomolecules and Biomedicine 2023, 24(2):230–237. Impact factor 3.4 (Q3). DOI: https://doi.org/10.17305/bb.2023.9757
  21. AlMuraikhi S, Anwardeen N, Doudin A, Sellami M, Domling A,
    Agouni A, Althani AA, and Elrayess MA. Antioxidative Stress Metabolic Pathways in Moderately Active Individuals. Metabolites 2023, 13(9), 973. Impact factor 4.1 (Q2). DOI: https://doi.org/10.3390/metabo13090973
  22. AlMuraikhi S, Anwardeen N, Doudin A, Sellami M, Domling A,
    Agouni A, Althani AA, and Elrayess MA. The Metabolic Switch of Physical Activity in Non-Obese Insulin Resistant Individuals. International Journal of Molecular Sciences 2023, 24(9), 7816. Impact factor 6.208 (Q1). DOI: https://doi.org/10.3390/ijms24097816
  23. Zahid MA, Abdelsam SS, Raiq H, Parray A, Korashy HM, Zeidan A, Elrayess MA, Agouni A*. Sestrin2 as a protective shield against cardiovascular disease. *Corresponding author. International Journal of Molecular Sciences 2023, 24(5):4880. Impact factor 6.208 (Q1). DOI: https://doi.org/10.3390/ijms24054880
  24. Sayed TH, Maayah ZH, Zeidan H, Agouni A, and Korashy HM. Insight into the Physiological and Pathological Roles of the Aryl Hydrocarbon Receptor Pathway in Glucose Homeostasis, Insulin Resistance, and Diabetes Development. Cellular & Molecular Biology Letters 2022, 27(1):103. Impact factor 8.702 (Q1). DOI: https://doi.org/10.1186/s11658-022-00397-7
  25. Al-Jaber H, Mohamed NA, Govindharajan VK, Taha S,  John J, Halim S, Alser M, Al-Muraikhy S, Anwardeen NR, Agouni A, Elhissi A, Al-Naemi HA, Al-Mansoori L, and Elrayess MA. In vitro and in vivo validation of GATA-3 suppression for in-duction of adipogenesis and improving insulin sensitivity. International Journal of Molecular Sciences 2022, 23(19):11142. Impact factor 6.208 (Q1). DOI: https://doi.org/10.3390/ijms231911142
  26. Al-Muraikhy S, Anwardeen N, Naeem A, Sellami M, Domling A, Agouni A, and Elrayess MA. Comparing the effect of physical activity on metabolic profiles between insulin-sensitive and insulin-resistant non-obese individuals. International Journal of Environmental Research and Public Health 2022,19(19):12169. Impact factor 4.614 (Q1). DOI: https://doi.org/10.3390/ijerph191912169
  27. Khan A, Parray A, Akhtar N, Agouni A, Kamran S, Pananchikkal SV, Priyanka R, Gad H, Ponirakis G, Petropoulos IN, Chen K, Tayyab K, Saqqur M, Shuaib A, Malik RA. Corneal nerve loss in patients with TIA and acute ischemic stroke in relation to circulating markers of inflammation and vascular integrity. Scientific Reports 2022, 12(1):3332. Impact factor 4.38 (Q1). DOI: https://doi.org/10.1038/s41598-022-07353-7
  28. Bouras A, Al-Maadeed M, Naseem H, Hussain S, Agouni A, Al-Salem M. Development of a Research Tracking System for Higher Education Institution Research Grants EPiC Series in Computing 2022, 86:109–120. DOI: http://hdl.handle.net/10576/41405
  29. Kerkadi A, Lathief S, Khial Y, Taleb T, Attieh G, Rahman MM, Shi Z, and Agouni A. The relationship between bone mineral density and body composition among Qatari women with a high rate of obesity: Qatar Biobank data. Frontiers in Nutrition 2022, 9:834007.Impact factor 6.57 (Q1). DOI: https://doi.org/10.3389/fnut.2022.834007
  30. El Atab O, Ghantous C, El-Zein N, Farhat R, Agouni A, Korashy HM, Zibara K, Zeidan A. Involvement of caveolae in hyperglycemia-induced changes in adiponectin and leptin expressions in vascular smooth muscle cells. European Journal of Pharmacology 2022, 919:174701.Impact factor 4.43 (Q2). DOI: https://doi.org/10.1016/j.ejphar.2021.174701   
  31. Akhtar S, Hourani S, Therachiyil L, Al-Dhfyan A, Agouni A, Zeidan A, Uddin S, Korashy HM. Epigenetic Regulations of Cancer Stem Cells by the Aryl Hydrocarbon Receptor. Seminars in Cancer Biology 2022, 83:177-196. Impact factor 17.01 (Q1). DOI: https://doi.org/10.1016/j.semcancer.2020.08.014
  32. Al-Muraikhy S, Sellami M, Domling A, Rizwana N, Agouni A, Al-Khelaifi F, Diboun I, Donati F, Botre F, Elrayess MA. Metabolic signature of leukocyte telomere length in elite male soccer players. Frontiers in Molecular Biosciences 2021, 8:727144. Impact factor 5.24 (Q2). DOI: https://doi.org/10.3389/fmolb.2021.727144
  33. Benameur T, Benameur N, Saidi N, Tartag S, Sayad H, Agouni A. Predicting factors of public awareness and perception about the quality, safety of drinking water and pollution incidents. Environmental Monitoring and Assessment 2021, 194(1):22. Impact factor 2.51(Q3). DOI: https://doi.org/10.1007/s10661-021-09557-2
  34. Kamareddine L, Ghantous CM , Allouch S, Al-Ashmar SA, Anlar G, Kannan S, Djouhri L, Korashy HM, Agouni A, Zeidan A. Between Inflammation and Autophagy: The Role of Leptin-Adiponectin Axis in Cardiac Remodeling. Journal of Inflammation Research 2021, 14:5349-5365.Impact factor 6.92 (Q1). DOI: https://doi.org/10.2147/JIR.S322231
  35. Dhulkifle H, Agouni A, Zeidan A, Talfat M, AlKuwari MS, Parray A, Korashy HM. The Impact of Exposure to Environmental Pollutants on Autism Spectrum Disorder: Role 4 of the Aryl Hydrocarbon Receptor/Cytochrome P450 Pathway. International Journal of Molecular Sciences 2021, 22(17), 9258.Impact factor 5.92 (Q1). DOI: https://doi.org/10.3390/ijms22179258  
  36. Kerkadi A,Alkudsi D, Hamad S, Alkeldi H, Salih R, Agouni A*. The Association Between Zinc and Copper Circulating Levels and Cardiometabolic Risk Factors in Adults: A Study of Qatar Biobank Data. *Corresponding author.  Nutrients 2021, 13(8), 2729.Impact factor 5.71 (Q1). DOI: https://doi.org/10.3390/nu13082729
  37. Abdelsalam SS, Pasha M, El-Gamal H,Hasan M,Elrayess MA, Zeidan A,Korashy HM, Agouni A*. Protein Tyrosine Phosphatase (PTP)-1B Inhibition Improves Endoplasmic Reticulum (ER) Stress-Impaired Angiogenic Response in Endothelial Cells: A Critical Role for Cell Survival. *Corresponding author. Molecular Medicine Reports 2021, 24(3):665.Impact factor 2.95 (Q3). DOI: https://doi.org/10.3892/mmr.2021.12304
  38. Jaam M, Nazar ZJ, Rainkie DC, Hassan D, Hussain FN, Kassab S, Agouni A. Impact of Rapid Transition to Distance-learning on Assessments in higher education: A qualitative study. PloS ONE 2021, 16(7):e0254444. Impact factor 3.24 (Q2). DOI: https://doi.org/10.1371/journal.pone.0254444
  39. Fatima TM, Hasan M, Abdelsalam SS, Sivaraman SK, El-Gamal H, Zahid MA, Elrayess MA, Korashy HM, Zeidan A, Parray A, Agouni A*. Sestrin2 suppression aggravates oxidative stress and apoptosis in endothelial cells subjected to pharmacologically induced endoplasmic reticulum stress. *Corresponding author. European Journal of Pharmacology 2021, 907:174247.Impact factor 4.43 (Q2). DOI: https://doi.org/10.1016/j.ejphar.2021.174247
  40. Zachariah M, Maamoun H, Milano L, Rayman MP, Meira LB, Agouni A*. Endoplasmic reticulum stress and oxidative stress drive endothelial dysfunction induced by high selenium. *Corresponding author. Journal of Cellular Physiology 2021, 236:4348-4359. Impact factor 6.38 (Q1). DOI: https://doi.org/10.1002/jcp.30175
  41. Alhoshani A, Alatwi FO, Al-Anzi FE, Attafi IM, Zeidan A, Agouni A, El-Gamal HM, Shamoon LS, Ghanim SS, Korashy HM. BCL-2 Inhibitor Venetoclax Suppresses Breast Cancer Cell Growth via Induction of Apoptosis, Cell Cycle Arrest, and Autophagy. OncoTargets and Therapy 2020, 2020(13): 13357—13370. Impact factor 3.33 (Q2). DOI: https://doi.org/10.2147/OTT.S281519 
  42. Osman A, El-Gamal H, Pasha M, Zeidan A, Korashy HM, Abdelsalam SS, Hasan M, Benameur T, Agouni A*. Endoplasmic Reticulum (ER) stress-generated extracellular vesicles (microparticles) self-perpetuate ER stress and mediate endothelial cell dysfunction independently of cell survival. *Corresponding author. Frontiers in Cardiovascular Medicine 2020, 7:584791. Impact factor 3.91 (Q2). DOI: https://doi.org/10.3389/fcvm.2020.584791
  43. Osman A, Benameur T, Korashy HM, Zeidan A, Agouni A*. Interplay between endoplasmic reticulum stress and large extracellular vesicles (microparticles) in endothelial cell dysfunction. *Corresponding author. Biomedicines 2020, 8(10):409.Impact factor 4.74 (Q1). DOI: https://doi.org/10.3390/biomedicines8100409
  44. Hussain FN, Al-Mannai R, Agouni A*. An emergency switch to distance learning in response to the COVID-19 pandemic: Experience from an internationally accredited undergraduate pharmacy program at Qatar University. *Corresponding author. Medical Science Educator 2020, 30:1393–1397. DOI: https://doi.org/10.1007/s40670-020-01079-9
  45. Al-Mansoori L, Al-Jaber H, Madani AY, Mazloum NA, Agouni A, Ramanjaneya M, Abou-Samra A, Elrayess MA. Suppression of GATA-3 increases adipogenesis, reduces inflammation and improves insulin sensitivity in 3T3L-1 preadipocytes. Cellular Signalling 2020, 75:109735. Impact factor 3.96 (Q2). DOI:  https://doi.org/10.1016/j.cellsig.2020.109735
  46. AlHoshani A, Alanazi FE, Alotaibi MR, Attwa MW, Kadi AA, Aldhfyan A, Akhtar S, Hourani S, Agouni A, Zeidan A, Korashy HM. EGFR Inhibitor Gefitinib Induces Cardiotoxicity through the Modulation of Cardiac PTEN/Akt/FoxO3a Pathway and Reactive Metabolites Formation: In Vivo and In Vitro Rat Studies. Chemical Research in Toxicology 2020, 33(7):1719-172. Impact factor 3.18 (Q2). DOI: https://doi.org/10.1021/acs.chemrestox.0c00005
  47. Hussain FN, Al-Mannai R, Diab MI, Agouni A*. Investigating the use of a lecture capture system within pharmacy education: Lessons from an internationally accredited undergraduate pharmacy program at Qatar University. *Corresponding author. International Journal of Educational Technology in Higher Education 2020, 17:40. Impact factor 3.08 (Q1). DOI: https://doi.org/10.1186/s41239-020-00214-1
  48. Ghantous CM, Farhat R, Al-Ashmar AS, Anlar G, Djouhri L, Korashy HM, Agouni A, Zeidan A. Molecular mechanisms of adiponectin-induced attenuation of mechanical stretch-mediated vascular remodeling. Oxidative Medicine and Cellular Longevity 2020, 2020:6425782. Impact factor 4.86 (Q2). DOI: https://doi.org/10.1155/2020/6425782
  49. Khudair N, Agouni A, El- Elrayess M, Najlah M, Younes HM, Elhissi A. Letrozole-loaded nonionic surfactant vesicles prepared via a slurry-based proniosome technology: Formulation development and characterization. Journal of Drug Delivery Science and Technology 2020, 58:101721. Impact factor 2.73 (Q2). DOI: https://doi.org/10.1016/j.jddst.2020.101721
  50. Ravindran H, Pasha M, Agouni A, Munusamy S. Microparticles As Potential Mediators of High Glucose-Mediated Renal Cell Injury. Biomolecules 2019, 9(8):348. Impact Factor 4.69 (Q2). DOI: https://doi.org/10.3390/biom9080348
  51. Abdelsalam SS, Korashy HM, Zeidan A, Agouni A*. The role of Protein Tyrosine Phosphatase (PTP)-1B in cardiovascular disease and its interplay with insulin resistance. *Corresponding author. Biomolecules 2019, 9(7):286. Impact Factor 4.69 (Q2). DOI: https://doi.org/10.3390/biom9070286 
  52. Ibrahim SAZ, Kerkadi A, Agouni A*. Selenium and health: An update on the situation in the Middle East and North Africa. *Corresponding author. Nutrients 2019, 11(7):1457. Impact Factor 4.17 (Q1). DOI: https://doi.org/10.3390/nu11071457
  53. Maamoun H, Abdelsalam SS, Zeidan A, Korashy HM, Agouni A*. Endoplasmic Reticulum Stress: A critical molecular driver of endothelial dysfunction and cardiovascular disturbances associated with diabetes. *Corresponding author. International Journal of Molecular Sciences 2019, 20(7):1658. Impact Factor 3.68 (Q2). DOI: https://doi.org/10.3390/ijms20071658
  54. Pasha M, Sivaraman SK, Frantz R, Agouni A*, Munusamy S*. Metformin Induces Different Responses in Clear Cell Renal Cell Carcinoma Caki Cell Lines. *Corresponding authors. Biomolecules 2019, 9(3):113. Impact Factor 4.69 (Q1). DOI: https://doi.org/10.3390/biom9030113
  55. El-Gamal H, Parray SA, Mir FA, Shuaib A, Agouni A*. Circulating Microparticles as Biomarkers of Stroke: A Focus on the Value of Endothelial- and Platelet-derived Microparticles. *Corresponding author. Journal of Cellular Physiology 2019, 234:16739–16754. Impact factor 4.55 (Q1). DOI: https://doi.org/10.1002/jcp.28499
  56. Agouni A*, Parray SA, Akhtar N, Mir FA, Bourke JP, Joseph S, Morgan D, Santos MD, Wadiwala FM, Kamran S, Sivaraman SK, Shuaib A. There is selective increase in pro-thrombotic circulating extracellular vesicles in acute ischemic stroke and transient ischemic attack: A study of patients from the Middle East and Southeast Asia. *Corresponding author. Frontiers in Neurology 2019, 10:251. Impact factor 3.5 (Q2). DOI: https://doi.org/10.3389/fneur.2019.00251
  57. Benameur T, Osman A, Parray A, Ait Hssain A, Munusamy S, Agouni A*. Molecular Mechanisms Underpinning Microparticle-mediated Cellular Injury in Cardiovascular Complications Associated with Diabetes. *Corresponding author. Oxidative Medicine and Cellular Longevity 2019, 2019:6475187.Impact factor 4.86 (Q2). DOI: https://doi.org/10.1155/2019/6475187
  58. MaamounH, Benameur T, Pintus G, Manusamy S, Agouni A*. Crosstalk Between Oxidative Stress and Endoplasmic Reticulum (ER) Stress in Endothelial Dysfunction and Aberrant Angiogenesis Associated with Diabetes: A Focus on the Protective Roles of Heme Oxygenase (HO)-1. *Corresponding author. Frontiers in Physiology 2019, 10:70. Impact factor 3.39 (Q1). DOI: https://doi.org/10.3389/fphys.2019.00070
  59. Fois A, Posadino AM, Giordo R, Cossu A, Agouni A, Rizk NM, Pirina P, Carru C, Zinellu A, Pintus G. Antioxidant activity mediates pirfenidone antifibrotic effect in human pulmonary vascular smooth muscle cells exposed to sera of idiopathic pulmonary fibrosis patients. Oxidative Medicine and Cellular Longevity 2018, 2018:2639081. Impact factor 4.93 (Q2). DOI: https://doi.org/10.1155/2018/2639081
  60. Agouni A, Mostefai HA, Lagrue AH, Sladkova M, Rouet P, Desmoulin F, Pechanova O, Martinez MC, Andriantsitohaina R. Paradoxical effect of non-alcoholic red-wine polyphenols extract, Provinols™, in the regulation of cyclo-oxygenases in vessels from zucker fatty rats (fa/fa). Oxidative Medicine and Cellular Longevity 2017, 2017:8536910.Impact factor 4.59 (Q2). DOI: https://doi.org/10.1155/2017/8536910
  61. Garavelo SM, Higuchi ML, Pereira JJ, Reis MM, Kawakami JT, Ikegami RN, Palomino SAP, Wadt NSY, Agouni A*. Comparison of the protective effects of individual components of particulated trans-Sialidase (PTCTS) – PTC and TS – against high cholesterol diet-induced atherosclerosis in rabbits. *Corresponding author. Biomed Research International 2017, 2017:7212985. Impact factor 2.13 (Q3). DOI: https://doi.org/10.1155/2017/7212985
  62. Maamoun H, Zachariah M, McVey JM, Green FR, and Agouni A*. Heme Oxygenase (HO)-1 induction prevents endoplasmic reticulum stress-mediated endothelial cell death and impaired angiogenic capacity. *Corresponding author. Biochemical Pharmacology 2017, 127:46-59.Impact factor 4.58 (Q1). DOI: https://doi.org/10.1016/j.bcp.2016.12.009
  63. Safiedeen Z, Rodriguez-Gomez I, Soleti R, Vaithilingam D, Agouni A, Andriantsitohaina R, Zibara K, Martinez MC. Temporal Cross Talk Between Endoplasmic Reticulum and Mitochondria Regulates Oxidative Stress and Mediates Microparticle-Induced Endothelial Dysfunction. Antioxidants & Redox Signaling 2017, 1:26(1):15-27. Impact factor 6.33 (Q1). DOI: https://doi.org/10.1089/ars.2016.6771
  64. Agouni A, Tual-Chalot S, Chalopin M, Duluc L, Martinez MC, Mody N, Andriantsitohaina R and Delibegović M. Hepatic protein tyrosine phosphatase 1B (PTP1B) deficiency protects against obesity-induced endothelial dysfunction. Biochemical Pharmacology 2014, 92(4):607-617. Impact factor 4.65 (Q1). DOI: https://doi.org/10.1016/j.bcp.2014.10.008
  65. Agouni A, Andriantsitohaina R, Martinez MC. Microparticles as biomarkers of vascular dysfunction in Metabolic Syndrome and its individual components. Current Vascular Pharmacology 2014, 12(3):483-92. Impact factor 2.82 (Q2). DOI: https://doi.org/10.2174/1570161112666140423223148  
  66. Grant L, Shearer K, Czopek A, Lees E, Owen C, Agouni A, Workman J, Martin-Granados C, Forrester JV, Wilson HM, Mody N, and Delibegovic M. Myeloid-cell protein tyrosine phosphatase-1B deficiency protects against high-fat diet and lipopolysaccharide induced inflammation, hyperinsulinemia and endotoxemia through an IL-10 STAT3 dependent mechanism. Diabetes 2014, 63(2):456-70. Impact factor 7.89 (Q1). DOI: https://doi.org/10.2337/db13-0885  
  67. Hoggard N, Agouni A, Mody N, and Delibegovic M. Serum Levels of Retinol Binding Protein 4 (RBP4) and Adipose Tissue Expression Levels of Protein Tyrosine Phosphatase 1B (PTP1B) are Increased in Obese Men Resident in Northeast of Scotland Without Any Changes in Endoplasmic Reticulum (ER) Stress Response Marker Genes. International Journal of General Medicine 2012, 5:403-11. DOI: https://doi.org/10.2147/IJGM.S25879
  68. Alnabulsi A, Agouni A, Mitra S, Garcia-Murillas I, Carpenter B, Bird S and Murray GI. Cellular apoptosis susceptibility (chromosome segregation 1-like, CSE1L) gene is a key regulator of apoptosis, migration and invasion in colorectal cancer. Journal of Pathology 2012, 4: 471-481.Impact factor 6.31 (Q1). DOI: https://doi.org/10.1002/path.4031
  69. Owen C, Czopek A, Agouni A, Judson R, Bence KK, Rosen E, Kahn B, Neel B, Mody N, and Delibegović M. Adipocyte-Specific Protein Tyrosine Phosphatase 1B Deletion Increases Lipogenesis, Adipocyte Cell Size and is a Minor Regulator of Glucose Homeostasis. PloS ONE 2012, 7(2):e32700. Impact factor 4.41(Q1). DOI: https://doi.org/10.1371/journal.pone.0032700 
  70. Agouni A, Ducluzeau PH, Benameur T, Faure S, Sladkova M, Duluc L, Leftheriotis G, Pechanova O, Delibegovic M, Martinez MC and Andriantsitohaina R. Microparticles from patients with metabolic syndrome induce vascular hypo-reactivity via Fas/Fas-Ligand pathway in mice. PloS ONE 2011, 6(11):e27809. Impact factor 4.41(Q1). DOI: https://doi.org/10.1371/journal.pone.0027809
  71. Agouni, A, Mody N, Owen C, Czopek A, Zimmer D, Bence K and Delibegović M. Liver-specific Deletion of Protein Tyrosine Phosphatase (PTP) 1B Improves Obesity- and Pharmacologically-Induced ER Stress and Reduces Oxidative and Nitrosative Stress. Biochemical Journal 2011, 438(2):369-78. Impact factor 4.00 (Q2). DOI: https://doi.org/10.1042/BJ20110373
  72. Mody N, Agouni A, Mcilroy GD, Platt B and Delibegovic M. Susceptibility to Diet-Induced Obesity and Glucose Intolerance in APPSWE/PSEN1A246E Alzheimer Mice is Associated with Decreased Brain pAkt/PKB Phosphorylation and Increased Erk1/2 and S6 Phosphorylation and RBP4 levels. Diabetologia 2011, 54(8):2143-51.Impact factor 6.55 (Q1). DOI: https://doi.org/10.1007/s00125-011-2160-2
  73. Banquet S, Delannoy E, Agouni A, Dessy C, Lacomme S, Hubert F, Richard V, Muller B and Leblais V. Role of Gi/o-Src kinase-PI3K/Akt pathway and caveolin-1 in β2-adrenoceptor coupling to endothelial NO Synthase in mouse pulmonary artery. Cellular signalling 2011, 23(7):1136-43.  Impact factor 4.24 (Q2). DOI: https://doi.org/10.1016/j.cellsig.2011.02.008
  74. Mastronardi ML, Mostefai HA, Soleti R, Agouni A, Martinez MC, and Andriantsitohaina R. Microparticles from apoptotic monocytes enhance nitrosative stress in human endothelial cells. Fundamental & Clinical Pharmacology 2011, 25(6):653-60. Impact factor 2.15 (Q3). DOI: https://doi.org/10.1111/j.1472-8206.2010.00898.x
  75. Agouni, A, Owen C, Czopek A, Mody N and Delibegović M. In vivo differential effects of fasting, re-feeding, insulin, and insulin stimulation time course on insulin signalling pathway components in peripheral insulin-sensitive tissues. Biochemical and Biophysical Research Communications 2010, 401(1):104-111. Impact factor 2.54 (Q3). DOI: https://doi.org/10.1016/j.bbrc.2010.09.018
  76. Priou P, Gagnadoux F, Tesse A, Mastronardi ML, Agouni A, Meslier N, Racineux JL, Martinez MC, Trzepizur W and Andriantsitohaina R. Endothelial nitric oxide dysfunction caused by circulating microparticles from patients with obstructive sleep apnea and severe nighttime hypoxia. American Journal of Pathology 2010,177(2):974-83. Impact factor 5.22 (Q1). DOI: https://doi.org/10.2353/ajpath.2010.091252
  77. Agouni A, Lagrue-Lak-Hal AH, Mostefai HA, Mulder P, Rouet P, Franck Desmoulin, Heymes C, Martinez MC, and Andriantsitohaina R. Red wine polyphenols prevent metabolic and cardiovascular alterations associated with obesity in zucker fatty rats (Fa/Fa). PLoS ONE 2009, 4(5):e5557.Impact factor 4.35 (Q1). DOI: https://doi.org/10.1371/journal.pone.0005557
  78. Agouni A, Lagrue-Lak-Hal AH, Ducluzeau PH, Mostefai HA, Draunet-Busson C, Leftheriotis G, Heymes C, Martinez MC and Andriantsitohaina R. Endothelial dysfunction caused by circulating microparticles from patients with metabolic syndrome. American Journal of Pathology2008, 173(4): 1210-1219. Impact factor 5.49 (Q1). DOI: https://doi.org/10.2353/ajpath.2008.080228
  79. Mostefai HA, Meziani F, Mastronardi ML, Agouni A, Sargentini C, Asfar P, Martinez MC and Andriantsitohaina R. Circulating microparticles from septic schock patients exert protective role on vascular function. American Journal of Respiratory and Critical Care Medicine 2008,178(11):1148-55.Impact factor 9.07 (Q1). DOI: https://doi.org/10.1164/rccm.200712-1835OC
  80. Mostefai HA#, Agouni A#, Carusio N, Mastronardi ML, Heymes C, Henrion D, Andriantsitohaina R and Martinez MC. PI3-Kinase and Xanthine oxidase regulate NO and oxygen reactive species productions by apoptotic lymphocyte microparticles in endothelial cells. #Co-fist authors. Journal of Immunology 2008, 180(7):5028-5035. Impact factor 6.3 (Q1). DOI: https://doi.org/10.4049/jimmunol.180.7.5028
  81. Agouni A, Mostefai HA, Porro C, Carusio N, Henrion D, Favre J, Richard V, Martinez MC and Andriantsitohaina R. Sonic hedgehog carried by microparticles corrects endothelial injury through nitric oxide release. FASEB Journal 2007, 21(11):2735-2741. Impact factor 6.72 (Q1). DOI: https://doi.org/10.1096/fj.07-8079com
  82. Agouni A, Sourbier C, Danilin S, Lindner V, Rothhut S, Helwig JJ, Lang H and Massfelder T.Parathyroid Hormone-Related Protein Induces Cell Survival through the phosphatidylinositol 3’-kinase/Akt Pathway in Renal Cell Carcinoma: Evidence for a Critical Role for Integrin-Linked Kinase and Nuclear Factor Kappa B. Carcinogenesis2007,28(9):1893-1901. Impact factor 5.4 (Q1). DOI: https://doi.org/10.1093/carcin/bgm106
  83. Sourbier C, Lindner V, Lang H, Agouni A, Talon I, Danilin S, Schordan E, Rothut S, Helwig JJ, and Massfelder T. The phosphatidylinositol 3-kinase/Akt pathway: A new target in human renal cell carcinoma therapy. Cancer Research 2006, 66(10):5130-5142. Impact factor 7.7 (Q1). DOI: https://doi.org/10.1158/0008-5472.CAN-05-1469