{"id":12,"date":"2022-08-25T10:09:09","date_gmt":"2022-08-25T10:09:09","guid":{"rendered":"http:\/\/qufaculty.qu.edu.qa\/ssif\/?page_id=12"},"modified":"2022-08-25T13:00:57","modified_gmt":"2022-08-25T13:00:57","slug":"publications","status":"publish","type":"page","link":"http:\/\/qufaculty.qu.edu.qa\/ssif\/publications\/","title":{"rendered":"Publications"},"content":{"rendered":"\n
  1. Alinari, L., K. Mahasenan, F. Yan, V. Karkhanis, J.-H. Chung, E. M. Smith, C. Quinion, P.L. Smith, L. Kim, J.T. Patton, R. Lapalombella, B. Yu, Y. Wu, S. Roy, A. De Leo, S. Pileri, C. Agostinelli, L. Ayers, J.E. Bradner, S. Chen-Kiang, O. Elemento, T. Motiwala, S. Majumder, J.C. Byrd, S. Jacob, S. Sif<\/strong>*, C. Li*, R.A. Baiocchi*. (2015). Selective inhibition of Protein Arginine Methyltransferase 5 blocks initiation and maintenance of B-cell transformation. Blood, <\/strong>125:2530-2543. (* indicates co-corresponding authors)<\/li>
  2. Nasipak, B.T., T. Padilla-Benavides, K.M. Green, J.D. Leszyk, W. Mao, S. Konda, S. Sif<\/strong>, S.A. Shaffer, Y. Ohkawa, A.N. Imbalzano. (2015). Opposing calcium-dependent signaling pathways mediate control of skeletal muscle differentiation by regulating a chromatin-remodeling enzyme. Nature Communications,<\/strong> 6:7441. Doi: 10.1038\/ncomms8441.<\/li>
  3. Hu Y.-J., H. Belaghzal, W.-Y Hsiao, J. Qi, J.E. Bradner, D.A. Guertin, S. Sif<\/strong>, A.N. Imbalzano. (2015). Transcriptional and post-transcriptional control of adipocyte differentiation by Jumonji domain-containing protein 6. Nucleic Acids Research,<\/strong> 43:7790-7804.<\/li>
  4. LeBlanc, S.E., Q. Wu, P. Lamba, S. Sif<\/strong>, A.N. Imbalzano. (2016). Promoter-enhancer looping at the PPARg2 locus during adipogenic differentiation requires the Prmt5 methyltransferase. Nucleic Acids Research,<\/strong> 44:5133-5147.<\/li>
  5. Banasavadi-Siddegowda, Y.K., L. Russell, E. Frair, V. Karkhanis, T. Relation, J.Y. Yoo, J. Zhang, S. Sif<\/strong>, J. Imitola, R. Baiocchi, B. Kaur. (2017). PRMT5-PTEN molecular pathway regulates senescence and self-renewal of primary glioblastoma neurosphere cells. Oncogene, <\/strong>36:263-274.<\/li>
  6. Huang, W., D. Mehta, S. Sif<\/strong>, L. Kent, S.T. Jacob, K. Goshal, K.D. Mehta. (2017). Dietary fat\/cholesterol-sensitive PKC\u03b2-RB signaling: Potential role in diet-induced NASH\/HCC axis. Oncotarget, <\/strong>43:73757-73765.<\/li>
  7. Smith, E., W. Zhou, P. Shindiapina, S. Sif<\/strong>, C. Li, R.A. Baiocchi. (2018). Recent advances in targeting protein arginine methyltransferase enzymes in cancer therapy. Expert Opin Ther Targets,<\/strong> 22:527-545.<\/li>
  8. Shailesh, H., Z. Zakaria, Baiocchi R, S. Sif<\/strong>. (2018). Protein arginine methyltransferase 5 (PRMT5) dysregulation in cancer cells. Oncotarget,<\/strong> 9:36705-36718.<\/li>
  9. Chung, J., V. Karkhanis, R.A. Baiocchi, S. Sif<\/strong>. (2019). Protein arginine methyltransferase 5 (PRMT5) promotes survival of lymphoma cells via activation of WNT\/\u03b2-CATENIN and AKT\/GSK3\u03b2 proliferative signaling. Journal of Biological Chemistry<\/strong>, 294:7692-7710.<\/li>
  10. Karkhanis, V., L. Alinari, H.G. Ozer, X. Zhang, S. Sif*<\/strong>,R.A. Baiocchi*. (2020). Protein arginine methyltransferase 5 directly targets and epigenetically silences microRNAs miR33b and miR96 to support constitutive CYCLIN D1 activity in non-Hodgkin\u2019s lymphoma. Journal of Biological Chemistry<\/strong>, 295:1165-1180. (* indicates co-corresponding authors).<\/li>
  11. Baiocchi, R.A., Li, C., Lai, H., Sif, S<\/strong>. (2020). Inhibitors of PRMT5 and methods of their use United States Ohio State Innovation Foundation (Columbus, OH, US) Patent no: 10723698 <\/strong>https:\/\/www.freepatentsonline.com\/10723698.html<\/a><\/li>
  12. Shailesh, H., K.S. Siveen, S. Sif<\/strong>. (2021). Protein arginine methyltransferase 5 (PRMT5) activates WNT\/\u03b2-CATENIN signaling in breast cancer cells via epigenetic silencing of DKK1 and DKK3. Journal of Cellular and Molecular Medicine<\/strong>, 25:1583-1600.<\/li><\/ol>\n\n\n\n

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    Alinari, L., K. Mahasenan, F. Yan, V. Karkhanis, J.-H. Chung, E. M. Smith, C. Quinion, P.L. Smith, L. Kim, J.T. […]<\/p>\n","protected":false},"author":1328,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-12","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"http:\/\/qufaculty.qu.edu.qa\/ssif\/wp-json\/wp\/v2\/pages\/12","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/qufaculty.qu.edu.qa\/ssif\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"http:\/\/qufaculty.qu.edu.qa\/ssif\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"http:\/\/qufaculty.qu.edu.qa\/ssif\/wp-json\/wp\/v2\/users\/1328"}],"replies":[{"embeddable":true,"href":"http:\/\/qufaculty.qu.edu.qa\/ssif\/wp-json\/wp\/v2\/comments?post=12"}],"version-history":[{"count":3,"href":"http:\/\/qufaculty.qu.edu.qa\/ssif\/wp-json\/wp\/v2\/pages\/12\/revisions"}],"predecessor-version":[{"id":44,"href":"http:\/\/qufaculty.qu.edu.qa\/ssif\/wp-json\/wp\/v2\/pages\/12\/revisions\/44"}],"wp:attachment":[{"href":"http:\/\/qufaculty.qu.edu.qa\/ssif\/wp-json\/wp\/v2\/media?parent=12"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}