Publications

  1. Alinari, L., K. Mahasenan, F. Yan, V. Karkhanis, J.-H. Chung, E. M. Smith, C. Quinion, P.L. Smith, L. Kim, J.T. Patton, R. Lapalombella, B. Yu, Y. Wu, S. Roy, A. De Leo, S. Pileri, C. Agostinelli, L. Ayers, J.E. Bradner, S. Chen-Kiang, O. Elemento, T. Motiwala, S. Majumder, J.C. Byrd, S. Jacob, S. Sif*, C. Li*, R.A. Baiocchi*. (2015). Selective inhibition of Protein Arginine Methyltransferase 5 blocks initiation and maintenance of B-cell transformation. Blood, 125:2530-2543. (* indicates co-corresponding authors)
  2. Nasipak, B.T., T. Padilla-Benavides, K.M. Green, J.D. Leszyk, W. Mao, S. Konda, S. Sif, S.A. Shaffer, Y. Ohkawa, A.N. Imbalzano. (2015). Opposing calcium-dependent signaling pathways mediate control of skeletal muscle differentiation by regulating a chromatin-remodeling enzyme. Nature Communications, 6:7441. Doi: 10.1038/ncomms8441.
  3. Hu Y.-J., H. Belaghzal, W.-Y Hsiao, J. Qi, J.E. Bradner, D.A. Guertin, S. Sif, A.N. Imbalzano. (2015). Transcriptional and post-transcriptional control of adipocyte differentiation by Jumonji domain-containing protein 6. Nucleic Acids Research, 43:7790-7804.
  4. LeBlanc, S.E., Q. Wu, P. Lamba, S. Sif, A.N. Imbalzano. (2016). Promoter-enhancer looping at the PPARg2 locus during adipogenic differentiation requires the Prmt5 methyltransferase. Nucleic Acids Research, 44:5133-5147.
  5. Banasavadi-Siddegowda, Y.K., L. Russell, E. Frair, V. Karkhanis, T. Relation, J.Y. Yoo, J. Zhang, S. Sif, J. Imitola, R. Baiocchi, B. Kaur. (2017). PRMT5-PTEN molecular pathway regulates senescence and self-renewal of primary glioblastoma neurosphere cells. Oncogene, 36:263-274.
  6. Huang, W., D. Mehta, S. Sif, L. Kent, S.T. Jacob, K. Goshal, K.D. Mehta. (2017). Dietary fat/cholesterol-sensitive PKCβ-RB signaling: Potential role in diet-induced NASH/HCC axis. Oncotarget, 43:73757-73765.
  7. Smith, E., W. Zhou, P. Shindiapina, S. Sif, C. Li, R.A. Baiocchi. (2018). Recent advances in targeting protein arginine methyltransferase enzymes in cancer therapy. Expert Opin Ther Targets, 22:527-545.
  8. Shailesh, H., Z. Zakaria, Baiocchi R, S. Sif. (2018). Protein arginine methyltransferase 5 (PRMT5) dysregulation in cancer cells. Oncotarget, 9:36705-36718.
  9. Chung, J., V. Karkhanis, R.A. Baiocchi, S. Sif. (2019). Protein arginine methyltransferase 5 (PRMT5) promotes survival of lymphoma cells via activation of WNT/β-CATENIN and AKT/GSK3β proliferative signaling. Journal of Biological Chemistry, 294:7692-7710.
  10. Karkhanis, V., L. Alinari, H.G. Ozer, X. Zhang, S. Sif*,R.A. Baiocchi*. (2020). Protein arginine methyltransferase 5 directly targets and epigenetically silences microRNAs miR33b and miR96 to support constitutive CYCLIN D1 activity in non-Hodgkin’s lymphoma. Journal of Biological Chemistry, 295:1165-1180. (* indicates co-corresponding authors).
  11. Baiocchi, R.A., Li, C., Lai, H., Sif, S. (2020). Inhibitors of PRMT5 and methods of their use United States Ohio State Innovation Foundation (Columbus, OH, US) Patent no: 10723698 https://www.freepatentsonline.com/10723698.html
  12. Shailesh, H., K.S. Siveen, S. Sif. (2021). Protein arginine methyltransferase 5 (PRMT5) activates WNT/β-CATENIN signaling in breast cancer cells via epigenetic silencing of DKK1 and DKK3. Journal of Cellular and Molecular Medicine, 25:1583-1600.

  1. Alinari, L., K. Mahasenan, F. Yan, V. Karkhanis, J.-H. Chung, E. M. Smith, C. Quinion, P.L. Smith, L. Kim, J.T. Patton, R. Lapalombella, B. Yu, Y. Wu, S. Roy, A. De Leo, S. Pileri, C. Agostinelli, L. Ayers, J.E. Bradner, S. Chen-Kiang, O. Elemento, T. Motiwala, S. Majumder, J.C. Byrd, S. Jacob, S. Sif*, C. Li*, R.A. Baiocchi*. (2015). Selective inhibition of Protein Arginine Methyltransferase 5 blocks initiation and maintenance of B-cell transformation. Blood, 125:2530-2543. (* indicates co-corresponding authors)
  2. Nasipak, B.T., T. Padilla-Benavides, K.M. Green, J.D. Leszyk, W. Mao, S. Konda, S. Sif, S.A. Shaffer, Y. Ohkawa, A.N. Imbalzano. (2015). Opposing calcium-dependent signaling pathways mediate control of skeletal muscle differentiation by regulating a chromatin-remodeling enzyme. Nature Communications, 6:7441. Doi: 10.1038/ncomms8441.
  3. Hu Y.-J., H. Belaghzal, W.-Y Hsiao, J. Qi, J.E. Bradner, D.A. Guertin, S. Sif, A.N. Imbalzano. (2015). Transcriptional and post-transcriptional control of adipocyte differentiation by Jumonji domain-containing protein 6. Nucleic Acids Research, 43:7790-7804.
  4. LeBlanc, S.E., Q. Wu, P. Lamba, S. Sif, A.N. Imbalzano. (2016). Promoter-enhancer looping at the PPARg2 locus during adipogenic differentiation requires the Prmt5 methyltransferase. Nucleic Acids Research, 44:5133-5147.
  5. Banasavadi-Siddegowda, Y.K., L. Russell, E. Frair, V. Karkhanis, T. Relation, J.Y. Yoo, J. Zhang, S. Sif, J. Imitola, R. Baiocchi, B. Kaur. (2017). PRMT5-PTEN molecular pathway regulates senescence and self-renewal of primary glioblastoma neurosphere cells. Oncogene, 36:263-274.
  6. Huang, W., D. Mehta, S. Sif, L. Kent, S.T. Jacob, K. Goshal, K.D. Mehta. (2017). Dietary fat/cholesterol-sensitive PKCβ-RB signaling: Potential role in diet-induced NASH/HCC axis. Oncotarget, 43:73757-73765.
  7. Smith, E., W. Zhou, P. Shindiapina, S. Sif, C. Li, R.A. Baiocchi. (2018). Recent advances in targeting protein arginine methyltransferase enzymes in cancer therapy. Expert Opin Ther Targets, 22:527-545.
  8. Shailesh, H., Z. Zakaria, Baiocchi R, S. Sif. (2018). Protein arginine methyltransferase 5 (PRMT5) dysregulation in cancer cells. Oncotarget, 9:36705-36718.
  9. Chung, J., V. Karkhanis, R.A. Baiocchi, S. Sif. (2019). Protein arginine methyltransferase 5 (PRMT5) promotes survival of lymphoma cells via activation of WNT/β-CATENIN and AKT/GSK3β proliferative signaling. Journal of Biological Chemistry, 294:7692-7710.
  10. Karkhanis, V., L. Alinari, H.G. Ozer, X. Zhang, S. Sif*,R.A. Baiocchi*. (2020). Protein arginine methyltransferase 5 directly targets and epigenetically silences microRNAs miR33b and miR96 to support constitutive CYCLIN D1 activity in non-Hodgkin’s lymphoma. Journal of Biological Chemistry, 295:1165-1180. (* indicates co-corresponding authors).
  11. Baiocchi, R.A., Li, C., Lai, H., Sif, S. (2020). Inhibitors of PRMT5 and methods of their use United States Ohio State Innovation Foundation (Columbus, OH, US) Patent no: 10723698 https://www.freepatentsonline.com/10723698.html
  12. Shailesh, H., K.S. Siveen, S. Sif. (2021). Protein arginine methyltransferase 5 (PRMT5) activates WNT/β-CATENIN signaling in breast cancer cells via epigenetic silencing of DKK1 and DKK3. Journal of Cellular and Molecular Medicine, 25:1583-1600.