RESEARCH
Patent Invention serial # 60/956,43: “In vitro and in vivo Tetracycline Inducible fluorescently-tagged protein expression system” Inventor: A Ouhtit (PI), Z Abd Elmageed (Co-PI), M Zerfaoui (Co-PI). LSU Health Sciences Center, Stanley S. Scott Cancer Center, N.O., LA. USA, 2007.
Publications (See the list of publications at the end): https://www.ncbi.nlm.nih.gov/pubmed/?term=Ouhtit
Extramural Funding:
CURRENT:
| Lead PI | Title | Number | Duration | Amount | Students | |
| Alaeddin Al Moustafa (L-PI) Allal Ouhtit: Co- LPI | Brain metastasis prediction using miRNA profiling in triple negative breast cancer: Potential biomarkers & therapeutic targets | Qatar national Research Foundation NPRP12S- 0308-190262 | 01/20 To 12/23 | $699,000.0 Pending | 1 PhD Student 1 Research Assistant | |
| Allal Ouhtit | Modulation of RNA Splicing for Therapeutic Purpose in Esophageal Adenocarcinoma | QU 152 | 01/20 To 12/21 | $100 000 | Research Assistant and PhD Student | |
| Allal Ouhtit | Novel transcriptional targets of CD44-downstream signaling as potential novel biomarkers for diagnosis/prognosis and/or targets for therapy of breast cancer | Qatar national Research Foundation UREP24-1171-027 | 01/20- 12/20 | $27,500 | 6 UG Students | |
| Haissam Abu Saleh (L-PI) Allal Ouhtit (CoPI) | Sildenafil-MIL-89 Conjugate as a Potential Drug Delivery Vehicle in Pulmonary Arterial Hypertension | Qatar national Research Foundation UREP22-1403-023 | 01/19- 01/20 | $15,000 | 2 UG Students | |
| Allal Ouhtit | The Novel role of BRIP1 in breast tumor development and progression | QUST-2-CAS2019-6 | 08/19- 11/19 | QR 20,000 | PhD Student | |
| Allal Ouhtit | Structural validation of E-Cadherin and Kynurenines as potential novel transcriptional downstream targets of CD146inhibited breast cancer cell invasion | QUST-2-CAS2019-5 | 08/20- 11/20 | QR 10,000 | 6 UG Students |
PREVIOUS:
At Qatar University:
| Lead PI | Title | Number | Duration | Amount | Students |
| Allal Ouhtit: Co-LPI | AMPK, mTOR and Tuberin: Novel Biological Pathways Linking Diabetes to Colorectal Cancer | Qatar national Research Foundation NPRP 5 – 409 – 3 – 112 | 11/2012 To 9/2016 | $1,021,337.0 | 3 UG Students 1 Postdoctoral fellow |
| Haissam Abu Saleh | Effect of Crude Extract from Qatari Medicinal Plants on Breast Cancer Cell Proliferation | Qatar national Research Foundation UREP21-0801-015 | 01/2018- 01/2019 | $54,000 | 3 UG Students |
| Allal Ouhtit | From Chemoprevention to Identification of Biomarkers and Potential Targets for Breast Cancer Therapy | QUST-1-CAS2019-22 | 25\04\20 16 until 31\12\20 16 | QR 120,000 | 4 UG Students And 1 PhD Student |
| Allal Ouhtit | The Novel role of BRIP11 in breast tumor development and progression | QUST-1-CAS2019-2 | 02/19 – 5/19 | QR 20,000 | Balsam Rizeq (PhD Student) |
| Allal Ouhtit | Structural validation of various CD44promoted tumor cell motility | QUST-1-CAS2019-3 | 02/19 – 5/19 | QR 10,000 | Rania Aledamat BSc |
| Allal Ouhtit | The novel function of BRIP1 in breast cancer progression | Ali Al-Suwaidi Trading Company | 06/2016 – 12/2016 | QR 50,000 | Balsam Rizeq (PhD Student) |
| Allal Ouhtit | Antimicrobial and Cytotoxic Activities of Selected Qatari Flora | QUST-1-CAS2018-4 | 14/01/18 31/12/18 | QR 20,000 | Wa’ed AlAbbasi |
| Allal Ouhtit | Genomics of breast cancer in Qatari Population | QUST-1-CAS2018-5 | 14/01/18 31/12/18 | QR 20,000 | Khaoula Errafii PhD Student |
| Allal Ouhtit | Mutation spectrum of S100P gene in breast tumors | QUST-CAS- SPR-2017-9 | 05\01\17 31\12\17 | QR 10,000 | Mona Yousif |
| Allal Ouhtit | The novel function of BRIP1 in breast cancer progression | QUST-CAS- SPR-15/16-14 | 09/06/16 31/12/16 | QR 40,000 | Balsam Riad Rizeq PhD Student |
| Allal Ouhtit | Mutation spectrum of BRIP1 gene in breast tumors | QUST-CAS- SPR-2017-10 | 05/01/16 31/12/16 | QR 10,000 | Noora AlThani |
At Previous institutions:
2014-2017 The Research Council(Ouhtit A: Co-investigator) $350 000
Title: Use of Natural Antioxidant and Anti-inflammatory Agents in Experimental Chronic Kidney Disease: Possible Benefits.
2014–2016 Sultan Qaboos University and UAE University(Ouhtit A: PI) $65 000
Title: Effects of the Combination “Camel Milk and Camel Urine”
In the chemoprevention of breast cancer: Nutrigenomic Studies
2010–2015 His Majesty’s Strategic Research Fund, Oman (Ouhtit A: Co-Investigator) $233 000
Title: Autism in Oman: Epidemiology and Etiology
2014-2016 Sultan Qaboos UniversityInternal Funding(Ouhtit A: PI) $36,000
Title: Establishment of Human Fibroblast Cultures for Genetic Testing in Oman
2010-2014 His Majesty’s Strategic Research Fund, Oman (Ouhtit A: PI) $310 000
Title: From Gene Expression Analysis of Omani Breast Tumours to Biomarkers/Candidate
Gene Discovery
2011-2013 Sultan Qaboos UniversityInternal Funding(Ouhtit A: PI) $36 500
Title: From Chemoprevention to Biomarkers and Target Development for Breast Cancer
2011-2013 Sultan Qaboos UniversityInternal Funding(Ouhtit A: Co-PI) $36 000
Title: Towards understanding the Genetics of Familial Bronchiectasis
2010-2012 Sultan Qaboos UniversityInternal Funding(Ouhtit A: PI) $36,000
Title: Novel Bardet-Biedl Syndrome (BBS) locus in Omani patients
2010–2011 Sultan Qaboos University and UAE University(Ouhtit A: Co-Investigator) $51,000
Title: Molecular Epidemiology and Diagnosis Study of Common
Inborn Errors of Metabolism Disorders in Oman and UAE
2010-2011 Sultan Qaboos UniversityInternal Funding(Ouhtit A: Co-PI) $53,000
Title: Integrative Investigation and Applied Molecular Epidemiology of Cystic Fibrosis in Oman.
2010-2012 Sultan Qaboos UniversityInternal Funding(Ouhtit A: Co-PI) $36,000
Title: The Relationship of Helicobacter pylori Infection with Prostatic and Bladder Diseases
2008-2009 RO3: NIH/NIAMS (1R03AR054960–01) (A Ouhtit: PI) $150,000 Title: Mechanisms of TL-01 Phototherapy of Psoriasis
2006-2009 Louisiana Cancer Research Consortium (A Ouhtit: PI) $450,000
Title: Mechanisms of CD146 in Breast Cancer
2006-2009 Louisiana Board of Regents (LABoR) Sponsored Projects (A Ouhtit: PI) $150,000
Title: Mechanisms of TL-01 Phototherapy of Psoriasis
2007-2009 LSUHSC Executive Research Council (A Ouhtit: PI) $86,000 Title: Dysfunction of Mesenchymal Stem Cell CD44-signaling
and their effect on Hematopoietic Stem Cell Phenotype.
2007-2011 PhD Award: The Egyptian Ministry of Higher Education (A. Ouhtit: Mentor) $140,000
Title: Understanding the Hyaluronan Signaling
2007-2009 Louisiana Cancer Research Consortium (Ouhtit A: Co-PI) $100,000
Title: Hyaluronan in Breast Cancer Stem Cell Metastasis to the Bone
2006-2007 The Susan G. Komen Breast Cancer Foundation ((A Ouhtit: PI) $120,000
Title: In vivo validation of CD44-inducible expression system in Breast Cancer Metastasis.
2006-2007 The Louisiana Cancer Research Consortium Initiative Award (A Ouhtit: PI) $60,000 Title: Distinct UV-specific p53 mutant-downstream signaling in the onset of Skin Cancer.
2003-2004 The Action Cancer Pilot Grant, UK (A. Ouhtit: PI) $20,000
Title: Dysfunction of the retinoblastoma pathway (p16/Rb), and Identification of Novel Genes associated with Melanoma Development
2003-2006 The Queens University Belfast DEL Ph D Award (A. Ouhtit: Mentor) $20,000
Title: Deregulation of apoptosis in UV-induced Non-Melanoma Skin Cancer
2001-2004 The Queens University Belfast DEL Ph D Award (A. Ouhtit: Mentor) $20,000 Title: Establishment of CD44-inducible system to study CD44 function in Breast Cancer
2002-2003 European Social Fund (A. Ouhtit: PI) $30,000
Title: Dysfunction of the p16/Rb pathway in UV-induced Melanoma:
2002-2003 Research & Development Northern Ireland (A. Ouhtit: PI) $15,000
Title: Mechanisms of UV-induced Non-Melanoma Skin Cancers
The Committee of Heads of Environmental Sciences – Institution of Environmental Sciences